Publications

Select Publications

36.    "More dynamic, more quantitative, unexpectedly intricate: advanced understanding on synaptic RNA localization in learning and memory." Roy R, Shiina N*, Wang DO*. Neurobiol Learn and Mem. 2019

35.    "Mapping m6A and m1A with mutational signatures. " Wang DO*. Nat Methods. 2019 (doi:10.1038/s41592-019-0636-z.)

34. "Neuropsychiatric disorders and RNA chemical marks at synapse." Sukegawa M, Wang DO.. Journal of Clinical and Experimental Medicine , Vol. 269 (11), p.811-812(2019).

33. "Nanoparticle-based local translation reveals mRNA as translation-coupled scaffold with anchoring function." Kashida S, Wang DO, Saito H, Gueroui Z*. PNAS , doi: 10.1073/pnas.1900310116.,(2019).

32. "Neuropsychiatric disorders and RNA chemical marks at synapse." Sukegawa M, Wang DO. Journal of Clinical and Experimental Medicine (Japanese) , 269, 811812 (2018).

31. "Functional partitioning of localized transcripts defined by m6A modification of mRNAs at synapse." ​Iida K, Wang DO. Japanese Experimental Medicine (Japanese), 36, (2018).

30. "Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts​" ​Merkurjev D, Hong WT, Iida K, Oomoto I, Goldie BJ, Yamaguti H, Ohara T, Kawaguchi S, Hirano T, Martin KC, Pellegrini M, Wang DO. Nature Neuroscience, 21, 10041014 (2018).

29. "Fe(II) ion release during endocytotic uptake of iron visualized by a membrane-anchoring Fe(II) fluorescent probe​" ​Niwa M, Hirayama T, Oomoto I, Wang DO, Nagasawa H. ACS Chemical Biology (2018) doi: 10.1021/acschembio.7b00939. This is work is featured in "ACS Editors’ Choice".

28. "Transport granules bound with nuclear cap binding protein and exon junction complex imply a role of pioneer round translation in mRNP remodeling in human neuronal processes. " ​Wang DO, Ninomiya K, Mori C, Koyama A Haan M, Kitabatake M, Hagiwara M, Chida K, Tahakashi S, Ohno M, Kataoka N. Front. Mol. Biosci (2017) doi.org/10.3389/fmolb.2017.00093

27. "miRNA enriched in human neuroblast nuclei bind the MAZ transcription factor and their precursors contain the MAZ consensus motif.​" Goldie BJ, Fitzsimmons C, Weidenhofer J. Atkins JR, Wang DO, and Cairns MJ. Front. Mol. Neurosci (2017) doi: 10.3389/fnmol.2017.00259 

26. "A modified single-cell electroporation method for molecule delivery into a motile protist, Euglena gracilis." Ohmachi M, Fujiwara Y, Muramatsu S, Yamada K, Iwata O, Suzuki K, Wang DO. J Microbiol Methods. Nov;130:106-111. doi: 10.1016/j.mimet.2016.08.018. Epub 2016 Aug 21 (2016) 

25. "ECHO-liveFISH: in vivo RNA Labeling Reveals Dynamic Regulation of Nuclear RNA Foci in Living Tissues" Oomoto I, Hirano-Suzuki A, Umeshima H, Han YW, Yanagisawa H, Carlton P, Harada Y, Kengaku M, Okamoto A, Shimogori T, and Wang DO. Nucl Acids. Res doi:10.1093/narlgkv614 (2015) 

24. "Hybridization-Sensitive Fluorescent Oligonucleotide Probe Conjugated with a Bulky Module for Compartment-Specific mRNA Monitoring in a Living Cell" Hayashi G, Yanase M, Takeda K, Sakakibara D, Sakamoto R, Wang DO, Okamoto A. Bioconjug Chem. (2015) PMID: 25710491 

23. "Live-cell Imaging of Endogenous mRNAs with a Small Molecule" Sato S, Watanabe M, Katsuda Y, Murata A, Wang DO, Uesugi M. Angew Chem Int Ed Engl. 2;54(6): 1855-8. (2015)

22. "ECHO-FISH for Gene Transcript Detection in Neuronal and Other Cells and Subcellular Compartments" Wang, DO, Okamoto A. Neuromethods, 99, in press. (2015)

21. "Visualization of Nucleic Acids with Synthetic Excitation-Controlled Fluorescent Oligonucleotide Probes."  Wang DO, Okamoto A. Methods Mol. Biol. 1262, 69-87.(2015)

20. "Plasma membrane translocation of a protein needle based on a triple-stranded β-helix motif." Sanghamitra. NJM, Inaba H, Arisaka F, Wang DO, Kanamaru S, Kitagawa S and Ueno T Mol. BioSyst (2014) DOI: 10.1039

19. "Localized cell stimulation by nitric oxide using a photoactive porous coordination polymer platform." Diring S, Wang DO, Kim C, Kondo M, Chen Y, Kitagawa S, Kamei K, Furukawa S Nat Commun 4:2684 (2013)

18. "A nucleic acid probe labeled with desmethyl thiazole orange: a new type of hybridization-sensitive fluorescent oligonucleotide for live-cell RNA imaging." Okamoto A, Sugizaki K, Yuki M, Yanagisawa H, Ikeda S, Sueoka T, Hayashi G, Wang DO. Org Biomol Chem 11(2): 362-71 (2013)

17. “ECHO probes: fluorescence emission control for nucleic acid imaging” Wang DO and Akimitsu Okamoto. Journal of Photochemistry and Photobiology, C: Photochemistry Reviews 13(2): 112-123 (2012)

16. “Identification of a cis-element that localizes mRNA to synapses” Meer E*, Wang DO*, Kim SM, Barr I, Guo F, and Martin KC. Proc Natl Acad Sci U S A 109 (12): 4639-44 (2012) (* Equal Contribution)

15. “Design of binary energy transfer on nucleic acids” Okamoto A, Ikeda S, Kubota T, Wang DO., Photomed. Photobiol 33, 45-46 (2011)

14. “Design and Synthesis of Caged Fluorescent Nucleotides and Application to Live Cell RNA Imaging” Ikeda S, Kubota T, Wang DO, Yanagisawa H, Umemoto T, Okamoto A., Chem Bio Chem 12(18):2871-80 (2011)

13. “A quick and simple FISH protocol with hybridization-sensitive fluorescent linear oligodeoxynucleotide probes” Wang DO*, Hitomi Matsuno, Shuji Ikeda, Hiroyuki Yanagisawa, Yasunori Hayashi, and Akimitsu Okamoto*., RNA 18(1):166-75 (2012) (* Corresponding authors)

12. “Emission Control by Binary Energy Transfer Processes on Oligouridine” Ikeda S, Kubota T, Wang DO, Yanagisawa H, Yuki M, Okamoto A., Org. Biomol. Chem 9(19):6598-603 (2011)

11. “Hybridization-sensitive fluorescence control in the near-infrared wavelength range” Ikeda S, Yanagisawa Y, Nakamura A, Wang DO, Yuki M, Okamoto A., Org. Biomol. Chem 9(11):4199-204 (2011)

10. “Spatially restricting gene expression by local translation at synapses” Wang DO, Martin KC, and Zukin RS. Trends Neurosci 33(4):173-82 (2010)

9. “Preparation of Aplysia sensory-motor neuronal cell cultures” Zhao Y, Wang DO, Martin KC., J Vis Exp 28 (2009)

8. “Synapse- and stimulus-specific local translation during long-term neuronal plasticity” Wang DO, Kim SM, Zhao Y, Hwang HG, Miura SK, Sossin WS, and Martin KC. Science 324(5934): 1536-40 (2009)
* This work was highlighted in a “Perspectives” article by M. Korte in the same issue of Science, featured as an “Editor’s choice” in Sci. Signal., 23 June 2009, selected as a “must read” article by Faculty of 1000, and featured in popular science media including Fortune, Yahoo news and BBC Focus.

7. “Trafficking of the plasma membrane GABA transporter GAT1: Size and rates of an acutely recycling pool” Wang D and Quick MW., J Biol Chem 280:18703-18709 (2005)

6. “Regulation of a gamma -aminobutyric acid (GABA) transporter by reciprocal tyrosine and serine phosphorylation” Quick MW, Hu J, Wang D, and Zhang HY., J Biol Chem 279:15961-15967 (2004).

5. “Syntaxin 1A inhibits GABA flux, efflux, and exchange mediated by the rat brain GABA transporter GAT1” Wang D, Deken SL, Whitworth TL and Quick MW., Mol Pharmacol 64:905-913 (2003)

4. “Plasma membrane GABA transporters reside on distinct vesicles and undergo rapid regulated recycling” Deken SL, Wang D and Quick MW. J Neurosci 23:1563-1568 (2003)

3. “Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions” Chiu CS, Jensen K, Sokolova I, Wang D, Li M, Deshpande P, Davidson N, Mody I, Quick MW, Quake SR and Lester HA. J Neurosci. 22:10251-10266 (2002)

2. “Dissociation of Pax-5 from KI and KII sites during kappa-chain gene rearrangement correlates with its association with the underphosphorylated form of retinoblastoma”. Sato H, Wang D and Kudo A., J Immunol. 166:6704-6710 (2001)

1. “The regulation of Ig rearrangement in bone marrow and spleen” Wang D and Kudo A., J Experimental Medicine 17:16-20 (1999)

Books

4. "Live Imaging of Nuclear RNPs in Mammalian Complex Tissue with ECHO-liveFISH" Wang DO. Methods in Molecular Biology. Vol 1649, doi.org/10.1007/978-1-4939-7213-5. (2017)

3. “Signaling between synapse and nucleus during synaptic plasticity” Lai KO, Wang D and Martin KC., Intracellular traffic and neurodegenerative orders, research and perspectives in Alzheimer’s disease, Springer-Verlag Berlin Heidelberg, pp71-85 (2008)

2. “Neurotransmitter transporters” Wang D, Hu J, Leitzell K, and Quick MW., Sibley D, Hanin I, Kuhar M and Skolnich P (ed.) The Handbook of Contemporary Neuropharmacology, John Wiley and Sons, Inc., New York (2007)

1. “Methods in studying the regulation and trafficking of transmembrane transporters” Deken SL, Wang D, and Quick MW. Transmembrane Transporters, John Wiley and Sons, Inc., New York, pp. 111-123 (2002)